Na+ Homeostasis in the Inner Ear.
10.3342/kjorl-hns.2010.53.7.399
- Author:
Sung Huhn KIM
1
;
Sang Cheol KIM
Author Information
1. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea. fledermaus@yuhs.ac
- Publication Type:Review
- Keywords:
Sodium;
Homeostasis;
Inner ear;
Cochlear;
Vestibule;
Endolymphatic sac
- MeSH:
Absorption;
Adenosine Triphosphate;
Ear, Inner;
Endolymphatic Sac;
Epithelial Cells;
Epithelium;
Hearing;
Homeostasis;
Membranes;
Receptors, Glucocorticoid;
Receptors, Purinergic;
Sodium
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2010;53(7):399-407
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Na+ homeostasis in the inner ear is important to maintain normal hearing and balance. Na+ transport in the inner ear is reported to be occurred in non-sensory epithelium of inner ear which forms a barrier between endolymphatic space and perilymphatic space. Functionally identified and constitutively active Na+ absorption sites in the inner ear are Reissner's membrane, outer sulcus cells, vestibular transitional cells, saccular nonsensory epithelial cells, and endolymphatic sac epithelial cells. Na+ transport in these epithelial cells is mediated by apically located epithelial Na+ channels (ENaC), nonselective cation channels and basolaterally located Na+, K+-ATPase. Na+ absorption is increased by glucocorticoid through glucocorticoid receptor or ATP through purinergic receptors depending on cell types.
