Localization of Cystic Fibrosis Transmembrane Conductance Regulator in Nasal Polyp Epithelial Cell.
- Author:
Yong Ju JANG
1
;
Jeong Hee CHO
;
Jae Hwan LEE
;
Chul Hee LEE
Author Information
1. Department of Otolaryngology, Dankook University College of Medicine, Chonan, Korea. yjang@anseo.dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Nasal polyp;
CFTR
- MeSH:
Animals;
Chloride Channels;
Cystic Fibrosis Transmembrane Conductance Regulator*;
Cystic Fibrosis*;
Cytoplasm;
Epithelial Cells*;
Epithelium;
Humans;
Kinetics;
Mice;
Nasal Polyps*;
Turbinates
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1999;42(2):193-196
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel protein that plays an important role in electrolyte and water transport, whose kinetics and localization are altered in cystic fibrosis (CF). Previous studies showed its presence in the apical domain of ciliated respiratory epithelial cells, and airway secretory glands. The purpose of this study was to characterize the localization of CFTR in the epithelium of nasal polyp of the subjects without phenotypic expression of cystic fibrosis. MAERIALS AND METHODS: Immunohistochemical staining for CFTR, using monoclonal mouse anti-human CFTR, were performed on tissue sections of 4 normal turbinate and nasal polyps from 10 patients who underwent intranasal operation. RESULTS: The nasal polyp epithelium demonstrated a heterogeneous pattern of CFTR expressions, including diffuse or scattered cytoplasmic labeling, very low to undetectable labeling, intense perinuclear staining, and typical apical location. CONCLUSION: These results suggest that abnormal expression and distribution of the CFTR may have a role in the formation of nasal polyp.
