Two Cases of Middle Ear Adenoma with Neuroendocrine Differentiation (Carcinoid Tumor).
10.3342/kjorl-hns.2011.54.8.573
- Author:
Bong Sik SHIN
1
;
Jae Ryong KIM
;
Hae Woong JEONG
;
Eun Kyoung KIM
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Inje University, Pusan Paik Hospital, Busan, Korea. jrkim53@hanmail.net
- Publication Type:Case Report
- Keywords:
Middle ear;
Carcinoid tumor
- MeSH:
Adenoma;
Bronchi;
Carcinoid Tumor;
Carcinoma, Neuroendocrine;
Ear, Middle;
Female;
Incidence;
Kidney;
Liver;
Lung;
Mediastinum;
Mucous Membrane;
Neoplasm Metastasis;
Neuroendocrine Cells;
Ovary;
Pancreas;
Prostate;
Recurrence;
Stem Cells;
Thymus Gland
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2011;54(8):573-577
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Middle ear adenoma with neuroendocrine differentiation (carcinoid tumor) is a rare benign tumor of the tympanic cavity. Carcinoid tumor is generally derived from primitive stem cells in the gut wall but can be seen in other organs, including the lungs, mediastinum, thymus, liver, pancreas, bronchus, ovaries, prostate, and kidneys. This is unusual considering neuroendocrine cells have not been identified in normal or inflamed middle ear mucosa. Carcinoid tumor of the middle ear represents a class within the spectrum of adenomatous neoplasms. Immunohistochemical techniques have helped clarify that these tumors all share elements of neuroendocrine differentiation. Although histologic and biological similarities with middle ear adenoma exist, carcinoid tumor of the middle ear should be classified as a well-differentiated neuroendocrine carcinoma because the carcinoid tumor has higher rate of recurrence and incidence of metastasis than middle ear adenoma. Surgical management is the recommended treatment and long-term observation is necessary.
