Understanding of Cementum Formation by the Wnt/β-Catenin Signaling.
10.17135/jdhs.2016.16.6.401
- Author:
Young Jae YOU
1
;
Jin Young YANG
Author Information
1. Department of Oral Anatomy and Histology, School of Dentistry, Chonbuk National University, Jeonju 54896, Korea. prime@dst.ac.kr
- Publication Type:Review
- Keywords:
Cementogenesis;
Dental cementum;
Epithelial mesenchymal transition;
Wnt signaling pathway
- MeSH:
Cementogenesis;
Dental Cementum*;
Epithelial Cells;
Epithelial-Mesenchymal Transition;
Periodontal Diseases;
Periodontal Ligament;
Regeneration;
Stomatognathic Diseases;
Tooth;
Wnt Signaling Pathway
- From:
Journal of Dental Hygiene Science
2016;16(6):401-408
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Periodontal disease is one of the major dental diseases. Currently, various methods are used for healing and successful regeneration of periodontal tissue damaged by periodontal disease. The periodontal ligament and alveolar bone have received considerable interest for use in periodontal tissue regeneration and induction. However, as the functions of the factors required for tooth attachment and key regulatory factors for periodontal tissue regeneration in the cementum have recently been identified, interest in cementum formation and regeneration has increased. Dental cementum forms in the late phase of tooth development because of the reciprocal regulatory interaction between cervical loop epithelial cells and surrounding mesenchymal cells, which is regulated by various gene signaling networks. Many attempts have been made to understand the regulatory factors and cellular and molecular mechanisms associated with new cementum formation. In this paper, we reviewed the study outcomes to date on the regulatory factors that induce cementum formation and regeneration, focusing on understanding the roles and functions of Wnt signaling in the regulation of cementum formation. In addition, we aimed to obtain information on the useful reciprocal regulatory factors that mediate cementum formation and regeneration through a series of molecular mechanisms.
