Prevention of overt diabetes and insulitis by BCG administration in the NOD mice of the breast-fed period.
- Author:
Tae Sun HWANG
1
;
Ho Suck KANG
;
Young Uck KIM
Author Information
1. Department of Anatomy, College of Medicine, Pochon CHA University, Pochon, Korea.
- Publication Type:Original Article
- Keywords:
BCG;
NOD mouse;
IDDM;
Timing of administraion
- MeSH:
Animals;
Autoimmune Diseases;
Diabetes Mellitus, Type 1;
Mice;
Mice, Inbred NOD*;
Mycobacterium bovis*
- From:Korean Journal of Anatomy
2000;33(1):49-54
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
By the concept that IDDM (insulin-dependent diabetes mellitus) is one of the autoimmune diseases, several immune suppressive drugs and immune modulators including BCG have been used to suppress the occurrence of IDDM. A data reported that BCG has different effects for prevention of diabetes according to the timing of drug administration. This study was performed to examine the preventive effect of diabetes development and insulitis by administering BCG at breast-fed period. NOD (non-obese diabetic) mice were divided into three groups: Group I, II, III were injected by BCG on the first day, eighth day, and twenty second day of life respectively. The later BCG was injected, the smaller occurrence of diabetes and the lower severity of insulitis were.
