Changes of Serum Alkaline Phosphatase and Osteocalcin during Fracture Healing.
10.4055/jkoa.2002.37.3.411
- Author:
Ho Seung LEE
1
;
Choon Sung LEE
;
Jae Suk JANG
;
Jae Dam LEE
;
Sung Moon UM
Author Information
1. Department of Orthopaedic Surgery, College of Medicine, Ulsan University, Seoul, Korea. hosng@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Fracture healing;
Osteoblastic marker;
Alkaline-phosphatase;
Osteocalcin
- MeSH:
Alkaline Phosphatase*;
Bony Callus;
Electrophoresis;
Enzyme-Linked Immunosorbent Assay;
Fracture Healing*;
Humans;
Osteoblasts;
Osteocalcin*
- From:The Journal of the Korean Orthopaedic Association
2002;37(3):411-415
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate changes of serum osteoblastic marker during fracture healing. MATERIALS AND METHODS: The study included 22 patients with fresh fractures. Serum alkaline phosphatase (ALP), bone specific alkaline phosphatase and osteocalcin were analyzed on the first day and 1, 2, 4 and 8 weeks after injury. The bone specific-ALP was quantified by electrophoresis. Osteocalcin was quantified by enzyme linked immunosorbent assay (ELISA). RESULTS: One, 2, 4 and 8 weeks after injury, mean values of serum ALP increased 1.26, 1.45, 1.63, and 1.2 times that on the first day after injury, respectively. Similarly, during the same period, bone specific ALP increased 1.38, 1.33, 1.73 and 1.25 times, and serum osteocalcins increased 1.32, 1.2, 1.64 and 2.09 times. CONCLUSION: Serum ALP increased during the early soft callus phase. However, serum osteocalcins increased during the late hard callus phase. Serum alkaline phosphatase and osteocalcin warrant further study as useful prognostic indicators of fracture healing.
