Severe Fever with Thrombocytopenia Syndrome.
10.4266/kjccm.2014.29.2.59
- Author:
Seung Jin YOO
1
;
Sang Taek HEO
;
Keun Hwa LEE
Author Information
1. Division of Infectious Disease, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea. neosangtaek@naver.com
- Publication Type:Review
- Keywords:
phlebovirus;
severe fever with thrombocytopenia syndrome;
Korea
- MeSH:
Bunyaviridae;
China;
Communicable Diseases, Emerging;
Cytokines;
Diagnosis;
Disease Progression;
Fever*;
Humans;
Immunoglobulin G;
Japan;
Korea;
Leukopenia;
Mortality;
Phlebovirus;
Polymerase Chain Reaction;
Risk Factors;
Thrombocytopenia*;
Tick-Borne Diseases
- From:The Korean Journal of Critical Care Medicine
2014;29(2):59-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease, caused by a novel species of Phlebovirus of Bunyaviridae family, in China, South Korea, and Japan. SFTS is primarily known as a tick-borne disease, and human-to-human transmission is also possible in contact with infectious blood. Common clinical manifestations include fever, thrombocytopenia, and leukopenia as initial symptoms, and multiple organ dysfunction and failure manifest with disease progression. Whereas disease mortality is reported to be 12% to 30% in China, a recent report of cumulative SFTS cases indicated 47% in Korea. Risk factors associated with SFTS were age, presence of neurologic disturbance, serum enzyme levels, and elevated concentrations of certain cytokines. Diagnosis of SFTS is based on viral isolation, viral identification by polymerase chain reaction, and serologic identification of specific immunoglobulin G. Therapeutic guideline has not been formulated, but conservative management is the mainstream of treatment to prevent disease progression and fatal complications.
