Unexpected Bleeding Following Endoscopic Sinus Surgery Leading to the Rare Diagnosis of Acquired Haemophilia A.
10.3342/kjorl-hns.2015.58.11.781
- Author:
Sung Hwan AHN
1
;
Yong Won KIM
;
Dong Hyuk IM
;
Jin Kook KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University School of Medicine, Seoul, Korea. entalk@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Acquired hemophilia A;
Endoscopic sinus surgery;
Factor VIII;
Factor VIII inhibitor;
Steroid
- MeSH:
Diagnosis*;
Epistaxis;
Factor VIII;
Hemophilia A*;
Hemorrhage*;
Humans;
Korea;
Methylprednisolone;
Middle Aged;
Nasal Polyps;
Partial Thromboplastin Time
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2015;58(11):781-785
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of acquired hemophilia A following endoscopic sinus surgery. The patient was a 64-year-old man whose preoperative activated partial thromboplastin time (aPTT) was slightly prolonged. He underwent endoscopic sinus surgery for chronic rhinosinusitis with nasal polyp. Nasal bleeding occurred spontaneously on the postoperative day 3. The aPTT was prolonged at 58.9 s, with factor VIII activity of 21% and a positive factor VIII inhibitor. Treatment with factor VIII and methylprednisolone resulted in remission within 1 month. This is the first of such case reported in Korea; the patient was treated by recombinant factor VIII replacement and steroid therapy.
