Expression of protein kinase C-gamma mRNA on the spinal cord in a rat model of neuropathic pain.
- Author:
Im Joo RHYU
1
;
Heung Sik NA
;
Backil SUNG
;
Yoon Hee KANG
;
Hyun KIM
;
Young Suk SUH
Author Information
1. Department of Anatomy, Korea University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Neuropathic pain;
PKC-gamma;
Dorsal horn of spinal cord
- MeSH:
Animals;
Burns;
Central Nervous System Sensitization;
Horns;
Hyperalgesia;
Models, Animal*;
Neuralgia*;
Peripheral Nerve Injuries;
Posterior Horn Cells;
Protein Kinases*;
Rats*;
RNA, Messenger*;
Spinal Cord*
- From:Korean Journal of Anatomy
1999;32(6):775-778
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Partial peripheral nerve injury occasionally results in neuropathic pain, including spontaneous burning pain and increased sensitivity to sensory stimuli such as hyperalgesia and allodynia. The pathophysiological mechanisms underlying this disease are poorly understood and the available treatments unsatisfactory. Presently, the neuropathic pain is believed to result from an increase in the excitability of the dorsal horn neurons (central sensitization), which is induced by abnormal signals from injured afferents. PKC-gamma is known to play a pivotal role in central sensitization following peripheral nerve injury. In the present study, we examine the expression of PKC-gamma mRNA of the spinal dorsal horn after neuropathic injury. There was no significant difference of PKC-gamma mRNA between lesion and control sides. These results suggest that PKC-gamma mRNA is not a key factor for the generation of neuropathic pain.
