Immunocytochemical Localization of Transforming Growth Factor-alpha in the Forebrain of the Rat.
- Author:
Yoon Young CHUNG
1
;
Sang Soo PARK
;
Sang Pil YOON
;
Jong Joong KIM
;
Jeong Seok MOON
;
Sang Bong JEONG
;
Hong Soon KIM
Author Information
1. Department of Anatomy, College of Medicine, Chosun University, Korea. yyjung@mail.chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Transforming growth factor-alpha;
Forebrain;
Rat;
Immunocytochemistry
- MeSH:
Adult;
Amygdala;
Animals;
Central Nervous System;
Cerebral Cortex;
Cerebrum;
Hippocampus;
Humans;
Hypothalamus;
Immunohistochemistry;
Neuroglia;
Neurons;
Prosencephalon*;
Pyramidal Cells;
Rats*;
Septum of Brain;
Thalamus;
Transforming Growth Factor alpha;
Ventral Thalamic Nuclei
- From:Korean Journal of Anatomy
2001;34(6):589-602
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The distribution of Transforming growth factor-alpha (TGF-alpha) was examined in the rat forebrain by immunocytochemistry. TGF-alpha immunoreactivity was observed in the cerebral hemispheres, thalamus and hypothalamus. Neurons in the olfactory and septal area, cerebral cortex, hippocampus, striatum, amygdala, and different nuclei of the thalamus and hypothalamus showed immunoreactivity. The intensity of the immunoreaction was high in the hippocampus, pyramidal cell layers of cerebral cortex, reticular and ventral thalamic nuclei, and paraventricular and supraoptic hypothalamic nuclei. In addition, a few labelled glial cells appeared at random in the forebrain. These results indicate that both neurons and glial cells appear to synthesize TGF-alpha in normal forebrain of the rat. However, TGF-alpha immunoreactivity was more widely distributed in neurons than glial cells. Therefore, although the role of TGF-alpha in the central nervous system remains elusive, the present data support the concept that TGF-alpha may act as a trophic factor in the adult rat forebrain.
