Prognostic Significance of Expression of Glutathione S-Transferase-pi and Multidrug Resistance-Associated Protein in Nasopharyngeal Carcinoma.
- Author:
Sang Chul LIM
1
;
Jae Shik CHO
;
Seung Hyun KIM
;
Pan Su KIM
;
Chang Guk KIM
;
Jae Hwan YOON
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Gwangju, Korea. cjscyy@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Nasopharyngeal carcinoma;
Multidrug resistance-associated proteins;
Glutathiones-transferase;
Immuno-histochemistry
- MeSH:
Cisplatin;
Drug Therapy;
Glutathione Transferase;
Glutathione*;
Incidence;
Jeollanam-do;
Multidrug Resistance-Associated Proteins*;
Nasopharyngeal Neoplasms;
Neoplasm Metastasis;
Paraffin;
Radiotherapy;
Survival Rate
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2002;45(8):791-795
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: For the treatment of nasopharyngeal carcinoma (NPC), radiation therapy is a primary option. Because of distant metastasis and the high incidence of a locoregional failure following radiotherapy, the combined treatment modality with chemotherapy is applied, although resistance to chemotherapy makes chemotherapy less effective. The Cisplatin-based chemotherapy has been widely used in the field of nasopharyngeal cancer. The Cisplatin resistance is known to be caused by the multidrug resistance-associated protein (MRP), which is one of the drug-export pumps and the glutathione S-transferase (GST)-pi which catalyzes the conjugation of the GSH (glutathione) and the cisplatin. The aim of this study is to determine the predictive value of GST-pi and MRP upon the response to cisplatin in nasopharyngeal carcinoma. SUBJECTS AND METHOD: We analyzed tumor tissues from 49 cases of paraffin block specimens which were diagnosed with NPC and treated at Chonnam National University Hospital. The immunohistochemical study for the GST-pi and the MRP was performed with paraffin block specimens of nasopharyngeal cancers. RESULTS: In the GST-pi, the relationship between the early stage (64.3%) and the advanced stage (91.4%) was statistically significant (p=0.020). The expression of the GST-pi and the MRP had no relationship with the clinical factor, the response to chemotherpy and the survival rate. CONCLUSION: Because the expression of the GST-pi and the MRP in the nasopharyngeal carcinoma could not predict the response to chemotherapy. So the efforts to find the predictive value of the chemotherapy are needed.
