The Prognostic Value of DNA Flow Cytometry in Patients with Early Primary Oral Cavity and Oropharyngeal Squamous Cell Carcinoma.
- Author:
Min Gwan KIM
1
;
Soon Yuhl NAM
;
Seung Joo YOO
;
Jae Gul CHUNG
;
Sang Yoon KIM
Author Information
1. Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
DNA flow cytometry Oral cavity cancer Oropharyngeal cancer Prognostic factor
- MeSH:
Aneuploidy;
Carcinoma, Squamous Cell*;
DNA*;
Flow Cytometry*;
Humans;
Mouth*;
Neck;
Neoplasm Metastasis;
Oropharyngeal Neoplasms;
S Phase;
Survival Rate
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2001;44(7):744-747
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUNDS AND OBJECTIVE: It has been known that tumor size, regional neck metastasis state and tumor thickness are the prognostic factors of oral cavity or oropharyngeal cancer. Additionally, DNA flow cytometry has also been reported to be one of the pronosic factors. We would like to evaluate the prognostic value of DNA flow cytometry in early oral cavity or oropharyngeal squamous cell carcinoma. MATERIALS AND METHODS: We analyzed the relation between tumor thickness or neck metastasis and survival rate in 59 patients with early oral cavity or oropharyngeal cancer. Among those patients, DNA flow cytometry was performed in 28 cases and the prognostic value of the parameters of DNA flow cytometry was analyzed. RESULTS: Overall, a 2-year survival rate of the patients was 90.1%. Neither tumor thickness nor neck metastasis state was related to the overall survival rate. Tumor thickness was not related to neck metastasis state, either. Of the parameters of the DNA flow cytometry, only the S phase fraction of aneuploidy was related to the overall survival rate (p=0.0288). Also the total proportion of aneuploidy was weakly related to the state of neck metastasis (p=0.0518). CONCLUSION: These results indicate that DNA flow cytometry can be used as a good complementary factor for predicting the overall survival or neck metastasis in patients with early primary oral cavity or oropharyngeal squamous cell carcinoma.
