SUV Analysis of PET Scan for Prognostic Factor of Head and Neck Cancer.
- Author:
Byeong Cheol LEE
1
;
Yoon Sang SHIM
;
Yong Sik LEE
;
Guk Haeng LEE
;
Nak Yoon SEONG
;
Seong Chool HONG
;
Heon Dae KIM
;
Byeong Il KIM
;
Kwang Yoon JUNG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tomography;
Emission-computed;
Head and neck neoplasms
- MeSH:
Biology;
Carcinoma, Squamous Cell;
Head and Neck Neoplasms*;
Head*;
Humans;
Positron-Emission Tomography*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2003;46(11):955-958
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Previous studies have shown that uptake of 18Fluoro-2-deoxy-glucose in head and neck cancer, as determined by the standardized uptake value (SUV) on positron emission tomography scan (PET scan), is associated with the biology of tumor. The aims of this study were to confirm the association with the biology of tumor and to establish whether a high SUV had prognostic significance. MATERIALS AND METHOD: Thirty patients with the head and neck cancer diagnosed as squamous cell carcinoma underwent a PET scan before treatment. SUVs were analyzed for possibility correlated with diseasefree survival. RESULTS: In univariate survival analysis, when patients were divided into two groups based on the SUV cut-off value of 8, the group whose SUV was greater than 8 in the pre-treatment PET scan showed significantly worse outcome (p=0.029). Correlation analysis demonstrated that SUV provided prognostic information independent of the tumor size, pathologic differentiation and stage. CONCLUSION: We conclude that high FDG uptake on PET (SUV >8 in pre-treatment PET scan) is an important prognostic indicator for poor outcome. Identified patients are thought to require intensive treatment protocol and more careful follow up.
