Clinical Effect of Tissue Plasminogen Activator in Vitreous Hemorrhage.
- Author:
Young Woo IM
1
;
Jung Il MOON
;
Sang Moon JUNG
Author Information
1. Department Ophthalmology, St.Mary's Hospital, Catholic University, Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tissue plasminogen activator;
Visual acuity;
Vitreous hemorrhage
- MeSH:
Fibrinolysis;
Humans;
Intraocular Pressure;
Plasminogen;
Tissue Plasminogen Activator*;
Visual Acuity;
Vitrectomy;
Vitreous Hemorrhage*
- From:Journal of the Korean Ophthalmological Society
1993;34(11):1135-1140
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
There has been several reports that tissue plasminogen activator(tPA) accelerated the fibrinolysis in vitreous cavity in-vivo. We investigated the efficacy of intravitreal tPA injection(25 microgram/100 microgram, 0.1 ml) for treatment of vitreous hemorrhage in non-vitrectomized patients(58 patients, 61 eyes). 1. Visual acuity was improved in 43 eyes(70.5%) and fundus was relatively well seen in 29 eyes(47.5%). 2. There were no clinical differences of intraocular pressure between before injection and the day after injection of tPA. 3, The complication of tPA injection were rebleeding(3 eyes, 4.9%) and inflammatory reaction(1 eyes, 1.6%). On these results, it appears that intravitreal tPA injection is useful for treatment of vitreous hemorrhage before vitrectomy.
