A Case of Asymptomatic Multiple Endocrine Neoplasia Type 1 Detected Incidentally on Health Screening.
10.3342/kjorl-hns.2012.55.6.373
- Author:
Pyung San CHO
1
;
Hoon PARK
;
Guk Haeng LEE
;
Myung Chul LEE
Author Information
1. Department of Otolarygology-Head & Neck Surgery, Korea Cancer Center Hospital, Seoul, Korea. lmc@daum.net
- Publication Type:Case Report
- Keywords:
Multiple endocrine neoplasia type 1;
Hyperparathyroidism;
Parathyroid hyperplasia;
Parathyroidectomy
- MeSH:
Adenoma;
Adrenalectomy;
Adrenocortical Adenoma;
Carcinoid Tumor;
Female;
Humans;
Hyperparathyroidism;
Hyperparathyroidism, Primary;
Hyperplasia;
Lipoma;
Mass Screening;
Middle Aged;
Multiple Endocrine Neoplasia;
Multiple Endocrine Neoplasia Type 1;
Parathyroidectomy;
Pituitary Neoplasms;
Pylorus
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2012;55(6):373-377
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple endocrine neoplasia type 1 (MEN 1) is characterized by the coexistence of primary hyperparathyroidism, enteropancreatic tumors, and anterior pituitary adenoma. Also adrenal adenoma, lipoma, carcinoid tumors could exist simultaneously on the atypical clinical course of MEN 1. Among these diseases, primary hyperparathyroidism is the most common manisfestation of MEN 1 syndrome. However, it sometimes presents no clinical symptoms and is incidentally detected on medical checkup. A 48-year-old woman, while undergoing a regular medical check-up, was diagnosed with primary hyperparathyroidism. Further studies showed concurrence of pancreatic tumor and adrenal tumor, but there was no pituitary lesion. The patient underwent parathyroidectomy with auto-implantation of parathyroid tissue, pylorus preserving pancreatico-duodenectomy and partial adrenalectomy. The pathological test confirmed it to be parathyroid hyperplasia, well-differentiated pancreatic endocrine carcinoma and adrenal cortical adenoma. We report this atypical and asymptomatic case of MEN 1 with a review of the relevant literature.
