Effects of Soy Protein, its Hydrolysate and Peptide Fraction on Lipid Metabolism and Appetite-Related Hormones in Rats.
10.4163/kjn.2010.43.4.342
- Author:
Ji Hye PARK
1
;
Mi Na PARK
;
Im Sik LEE
;
Yong Ki KIM
;
Wan Sik KIM
;
Yeon Sook LEE
Author Information
1. Department of Food and Nutrition & Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea. lysook@snu.ac.kr
- Publication Type:Original Article
- Keywords:
soy protein;
hydrolysate;
macro-peptide fraction;
lipid;
appetite
- MeSH:
Animals;
Appetite;
Diet;
Ghrelin;
Humans;
Leptin;
Lipid Metabolism;
Male;
Nitrogen;
Rats;
Rats, Sprague-Dawley;
Soybean Proteins;
Weight Gain
- From:The Korean Journal of Nutrition
2010;43(4):342-350
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was aimed to investigate whether soy protein hydrolysates had beneficial effects on serum and tissue lipid contents and appetite-related hormones as compared with intact soy protein. Four-week-old male Sprague-Dawley rats were fed AIN-93M diet containing high fat (18% w/w) with low protein (10% w/w). After four weeks, the rats were divided into four groups (n = 8/group) and fed experimental diets with different nitrogen sources and levels, respectively; 10% soy protein isolate (10SPI), 25% soy protein isolate (25SPI), 25% soy protein hydrolysates (25SPH) and 25% soy macro-peptide fractions (25SPP, MW > or = 10,000) for six weeks. Weight gain was significantly higher in 25% nitrogen sources-fed groups than in 10% group (10SPI). In 25SPP, perirenal fat mass and serum total lipid were significantly lower than in other groups. As for appetite-related hormones, serum ghrelin concentration was not shown to be different among groups but leptin concentration was significantly decreased in 25SPP. It can be concluded that soy macro-peptide fractions as compared with intact soy protein may have beneficial effects on reducing fat mass and serum lipid.
