Effect of Fermented Yacon (Smallanthus Sonchifolius) Leaves Tea on Blood Glucose Levels and Glucose Metabolism in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice.
10.4163/kjn.2010.43.4.333
- Author:
In Sook KIM
1
;
Jin LEE
;
Jeom Sook LEE
;
Dong Young SHIN
;
Myung Joo KIM
;
Mi Kyung LEE
Author Information
1. Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540-742, Korea.
- Publication Type:Original Article
- Keywords:
fermentated yacon leaves tea;
type 2 diabetes;
glucose metabolism
- MeSH:
Animals;
Blood Glucose;
Diet, High-Fat;
Glucokinase;
Glucose;
Hemoglobin A, Glycosylated;
Humans;
Injections, Intraperitoneal;
Insulin;
Insulin Resistance;
Leptin;
Male;
Mice;
Mice, Inbred ICR;
Plasma;
Tea;
Water
- From:The Korean Journal of Nutrition
2010;43(4):333-341
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The aim of this study was to investigate the hypolgycemic activity of water extract of fermented yacon (Smallanthus sonchifolius) leaves tea (Yacon LWE) in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice. Male ICR mice were fed with a HFD (37% calories from fat) for 4 weeks prior to intraperitoneal injection with STZ (100 mg/kg body weight). Diabetic mice were supplemented with two doses of Yacon LWE (0.16% and 0.8%, wt/wt) for 6 weeks. The supplementation of high-dose Yacon LWE significantly lowered blood glucose levels and plasma ALT and AST activities compared with the control group. High-dose Yacon LWE also improved the insulin tolerance without any changes in plasma and pancreatic insulin concentrations in HFD/STZ-induced diabetic mice. Yacon LWE supplementation increased the insulin staining of pancreatic beta-cells in a dose-dependent manner. Both 0.16% and 0.8% of Yacon LWE significantly elevated plasma leptin concentration, hepatic glucokinase activity and glucokinase/glucose-6-phosphatase ratio compared with the control group. However, glycosylated hemoglobin concentration was not different among the groups. These results suggest that high-dose Yacon LWE lowers the blood glucose level partly by enhancing insulin sensitivity and hepatic glucose metabolism in type 2 diabetic mice.
