Cyclosporine-Associated Central Neurotoxicity after Hearat Transplantation: 1 Case Report.
- Author:
Young Hee KIM
1
;
Hyun SONG
;
Meong Gun SONG
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, University of Ulsan, Asan Medical Center, Korea.
- Publication Type:Case Report
- Keywords:
Heart transplantation;
Cyclosporine;
Toxicity
- MeSH:
Cardiomyopathy, Dilated;
Coma;
Creatinine;
Cyclosporine;
Heart Transplantation;
Humans;
Magnesium;
Middle Aged;
Pupil;
Reflex
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1997;30(11):1136-1138
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 45-year-old man underwent heart transplantation due to dilated cardiomyopathy. Cyclosporine, 2 mg/kg per day, was intravenously given postoperatively. As central neurotoxicity signs that were included pin-point pupil, no light reflex, coma, were presented at 8 postoperative hours, cyclosporine was decreased to 1 mg/kg per day. At that time the cyclosporine level was 345 micro gram/L, the serum creatinine level was 1.8mg/dl and the serum magnesium level was within normal limit. He awaked at 31 postoperative hours and all sign of cyclosporine-induced central neurotoxicity was resolved after postoperative days. He was discharged without sequale at postoperative day 28.
