Study of Bone Quality and Growth Characteristics of Growth Plate following Limb Transplantation between Animals of Different Ages-results of an Experimental Study on Male Syngeneic Rats.
10.4055/jkoa.2007.42.5.644
- Author:
Tae Hyeong KIM
1
;
Hae Ryong SONG
;
Eun Mi CHUN
;
Jae Hyuk YANG
;
Seung Woo SUH
Author Information
1. Department of Orthopedic Surgery, College of Medicine, Korea University Guro Hospital, Korea. spine@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Growth plate;
Osteoporosis;
Limb transplant;
Isochronograft;
Heterochronograft;
Transplantation
- MeSH:
Adult;
Animals*;
Extremities*;
Growth Plate*;
Humans;
Male*;
Osteoporosis;
Rats*;
Tibia;
Tissue Donors;
Transplantation;
Transplants
- From:The Journal of the Korean Orthopaedic Association
2007;42(5):644-652
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Osteoporosis of transplanted/grafted bone is well known in the immediate post bone transplantation/bone grafting period. In limb transplantation, the growth plates in the transplanted limbs retain their longitudinal growth properties. However, there is a paucity of reports on what happens to the bone and the growth potential of the growth plate when limb transplantation between a juvenile donor and an adult recipient is performed. MATERIALS AND METHODS: Ten juvenile to juvenile hind limb transplants and five juvenile to adult hind limb transplants were performed in male syngeneic Lewis rats. Osteoporosis in the isochronograft as well as the heterochronograft limbs was measured by 3D micro-CT. In addition, the increase in tibial length, after transplantation was measured and compared with the increase in the tibial length of the opposite non-operated limbs. RESULTS: The 3D CT parameters indicate a significantly inferior bone quality in the heterochronografts compared with the isochronografts. After transplantation, the increase in the tibial length of the isochronografts was similar the increase in length of the opposite juvenile non operated tibiae and the heterochronograft tibias. CONCLUSION: Age is a significant factor that affects the bone quality, resulting in post transplant osteoporosis in heterochronografts compared with isochronografts. However, the growth plate after transplantation remains unaffected by the difference in age and continues to grow at its own inherent rate in adult recipients as it does in the juvenile recipients.
