Pattern of Hippocampal Cell Changes in Cobalt/Homocysteineinduced Status Epilepticus.
- Author:
Hyon Mee CHUN
1
;
Jae Moon KIM
;
Young Ho LEE
Author Information
1. Department of Anatomy, College of Medicine, Chungnam National University, Daejeon, Korea. yhlee@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Status epilepticus;
Hippocampus;
Cobalt/homocysteine;
Cell injury;
c-Jun immunoreactivity;
Secondary generalized epilepsy
- MeSH:
Animals;
Brain;
Cerebral Cortex;
Cobalt;
Dentate Gyrus;
Epilepsy, Generalized;
Hippocampus;
Homocysteine;
Immunohistochemistry;
Neurons;
Rats;
Status Epilepticus*;
Up-Regulation
- From:Korean Journal of Anatomy
2002;35(1):37-42
- CountryRepublic of Korea
- Language:English
-
Abstract:
Status epilepticus (SE) can be induced with homocysteine after pretreatment with cobalt. In order to investigate the pattern of neuronal changes in the hippocampus in cobalt/homocysteine-induced SE, H-E staining and immunohistochemistry for c-Jun were performed in the brain after SE. Neuronal damage was not seen in the hippocampus in cobalt-treated control rats. Neuronal injury occurred in 14% of the cells in the hilus 24 hrs after SE. The neuronal injury was minimal in the dentate gyrus (DG), CA3, and CA1 24 hrs after SE. c-Jun immunoreactivity was detected strongly in the DG and CA3 2 hrs after SE, and then c-Jun immunoreactivity was decreased to that of control rats in the hippocampus 24 hrs after SE. These results suggest that upregulation of c-Jun expression in the hippocampus is not related to neuronal death in cobalt/homocysteine-induced SE, secondary generalized epilepsy originating from the cerebral cortex does not cause significant hippocampal cell injury.
