Elevated Serotonin-immunoreactive Neurons in the Raphe Nucleus of the Ataxic Mutant Mouse, Pogo.
- Author:
Chul Tae KIM
1
;
Seung Yun HAN
;
Jae Hyun JEONG
;
Dae Sung YOON
;
Seoul LEE
;
Richard HAWKES
;
Nam Seob LEE
;
Young Gil JEONG
Author Information
1. Department of Anatomy and General Surgery, College of Medicine, Konyang University, Korea. ygjeong@konyang.ac.kr
- Publication Type:Original Article
- Keywords:
Serotonin;
Raphe nucleus;
Pogo;
Ataxia
- MeSH:
Animals;
Ataxia;
Hindlimb;
Immunohistochemistry;
Mice*;
Neurons*;
Phenotype;
Raphe Nuclei*;
Serotonin
- From:Korean Journal of Anatomy
2005;38(5):395-402
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was carried out to investigate the distribution of serotonin-immunoreactive neruons in the raphe nucleus of the ataxic pogo (pogo/pogo) mice derived from a Korean wild mice. Using by immunohistochemistry, we undertook to elucidate any correlation between the serotonin expression and behavior ataxia including abnormal hindlimb extension in the ataxic pogo mice. The present study has two important findings. First, serotonin immunoreactivity was increased in the raphe nucleus of the ataxic pogo mice. Second, serotonin immunoreactivity was different with the region of raphe nucleus. In the dorsal part of dorsal raphe nucleus (DRD), ventrolateral part of dorsal raphe nucleus (DRVL) and median raphe nucleus (MR), serotonin immunoreactivity was increased, whereas the ventral part of dorsal raphe nucleus (DRV) and interfascicular part of dorsal raphe nucleus (DRI) was similar with the control mice. Therefore, elevated expression of the serotonin in the raphe nucleus of ataxic pogo mice might be a source of behavior ataxia and may be related with the induction of the ataxic phenotype including abnormal hindlimb movements.
