The Factors Involved in Bilateral Central Lymph Node Metastasis of Isthmus Papillary Thyroid Cancer.
10.3342/kjorl-hns.2016.17335
- Author:
Keun Ik YI
1
;
Soo Geun WANG
;
Byung Joo LEE
;
In Ju KIM
;
Bo Hyun KIM
;
Sang Soo KIM
;
Jin Choon LEE
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Lymphatic metastasis;
Neck dissection;
Papillary thyroid carcinoma;
Thyroid gland
- MeSH:
Humans;
Lymph Nodes*;
Lymphatic Metastasis;
Methods;
Multivariate Analysis;
Neck Dissection;
Neoplasm Metastasis*;
Risk Factors;
Thyroid Gland*;
Thyroid Neoplasms*;
Thyroidectomy
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2017;60(3):125-134
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The aims of this study were to evaluate the rate and risk factors involved in bilateral central lymph node metastasis in patients with papillary thyroid cancer (PTC) found in the isthmus and compared them to tumors located in other thyroid regions, using those findings to establish a surgical strategy for treating these tumors. SUBJECTS AND METHOD: We compared the clinical and pathological data of 48 patients with isthmic PTC and 141 patients with PTC found in other thyroid regions, all of whom underwent total thyroidectomy and bilateral central neck dissection. RESULTS: The rates of bilateral central lymph node metastasis were higher in the isthmus group than in the non-isthmus group (29.2% vs. 9.9%; p=0.001). On multivariate analysis, the isthmic location of the tumor was an independent risk factor for bilateral central lymph node metastasis (OR=3.458; p=0.005). But the positional relationship between the tracheal midline and the nodule was not clear in lymph node metastasis in the isthmus group. CONCLUSION: Bilateral central neck dissection should be considered for isthmic PTC regardless of the relation between nodule and tracheal midline because of the high rate of bilateral central lymph node metastasis.
