Pathogenesis of Transplant Glomerulopathy.
10.4285/jkstn.2011.25.2.71
- Author:
Beom Jin LIM
1
;
Hyeon Joo JEONG
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. jeong10@yuhs.ac
- Publication Type:Review
- Keywords:
Kidney glomerulus;
Kidney transplantation;
Graft rejection;
Humoral immunity
- MeSH:
Capillaries;
Endothelial Cells;
Glomerular Basement Membrane;
Graft Rejection;
Immunity, Humoral;
Kidney Glomerulus;
Kidney Transplantation;
Microscopy, Electron;
Transplants
- From:The Journal of the Korean Society for Transplantation
2011;25(2):71-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Transplant glomerulopathy is a late complication of renal transplantation. The characteristic morphology of transplant glomerulopathy includes thickening of glomerular capillary loops with double contour, and duplication of glomerular basement membrane on electron microscopy. Clinical and experimental evidences support the role of antibody-mediated immune mechanism in the development of transplant glomerulopathy. Antibody-induced endothelial cell injury is the key pathogenesis of transplant glomerulopathy. The evolution of transplant glomerulopathy in the context of immunologic injury is briefly reviewed.
