Expression of Vascular Cell Adhesion Molecule-1 on Vascular Endothelium in Nasal Polyps with Topical Steroid Treatment.
- Author:
Yang Gi MIN
1
;
Young Ho JUNG
;
Jeong Whun KIM
;
Chae Seo RHEE
;
Seung Sin LEE
;
Tae Bin WON
;
Seung Jun OH
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Vascular cell adhesion molecule-1;
Nasal polyps;
Steroids;
Vascular endothelium
- MeSH:
Biopsy;
Cell Adhesion;
Diethylpropion;
Endothelium, Vascular*;
Humans;
Nasal Polyps*;
Steroids;
Turbinates;
Vascular Cell Adhesion Molecule-1*;
Fluticasone
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2001;44(11):1164-1167
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Topical steroid therapy may play an important role in reducing the vascular cell adhesion molecule-1(VCAM-1) expression in the nasal polyp. Various adhesion molecules such as VCAM-1 promote formation of nasal polyp and they show different sensitivity to steroid therapy. Changes in the VCAM-1 expression after a 8-week intranasal steroid treatment were investigated. MATERIALS AND METHODS: The endothelial expression of VCAM-1 in biopsy specimens from the nasal polyps and inferior turbinates was investigated using the immunohistochemical staining in 20 patients with nasal polyposis. Biopsy specimens were obtained before, immediately after and 2 months after treatment with 100g fluticasone propionate in each nostril twice daily. The immunohistochemical activity in pretreatment and posttreatment specimens was analyzed. RESULTS: The VCAM-1 expression was significantly higher in the nasal polyps than in inferior turbinates(p=0.002). Immediately after the treatment, the VCAM-1 expression in the nasal polyps was significantly reduced(p=0.001). But the VCAM-1 expression in nasal polyps returned to the pretreatment level 2 months after the treatment. CONCLUSIONS: Intranasal steroid therapy may have an anti-inflammatory effect on nasal polyps by down regulating the VCAM-1 expression
