Survival of Spiral Ganglion.
10.3342/kjorl-hns.2009.52.11.869
- Author:
Chang Hyun CHO
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Gachon University of Medicine & Science, Graduate School of Medicine, Incheon, Korea. chochmd@gilhospital.com
- Publication Type:Review
- Keywords:
Spiral ganglion;
Neurotophic factor;
Survival;
Regeneration
- MeSH:
Cell Death;
Cochlear Implantation;
Cochlear Implants;
Hair;
Membranes;
Nerve Growth Factors;
Neurobiology;
Neuroglia;
Neurons;
Regeneration;
Spiral Ganglion;
Stem Cell Transplantation
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2009;52(11):869-873
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Survival and regeneration of spiral ganglion neuron (SGN) following deafening carries critical implication for cochlear implantation as well as reinnervation of restored hair cells. Survival and development of SGN depend on neurotrophic factors supplied by hair cells glial cells and other targets. The membrane electrical activity of spiral ganglion neurons also support their survival. Cell death inhibitors can also preserve spiral ganglion neurons. Recent studies of spiral ganglion survival including stem cell transplantation have identified several neurotrophic factors which protect neurons from death following hair cell loss. Although these experimental results are still preliminary, progression in study of strategy for SGN survival should be an important part of future neurobiology.
