Expression of Cyclin D1 Protein and Ki-67 Index in Advanced Squamous Cell Carcinomas of Head and Neck and Correlation with Response to Chemotherapy and Radiotherapy.
- Author:
Sang Hyun KIM
1
;
Byung Yoon CHOI
;
Dong Jo HWANG
Author Information
1. Department Otolaryngology, National Medical Center, Seoul, Korea. skimnmc@chollian.dacom.co.kr
- Publication Type:Original Article
- Keywords:
Cyclin D1;
Ki-67;
Chemotherapy;
Radiotherapy;
Head and Neck Squamous cell carcinoma
- MeSH:
Antibodies, Monoclonal;
Carcinoma, Squamous Cell*;
Chemoradiotherapy;
Cyclin D1*;
Cyclins*;
Drug Therapy*;
Head*;
Humans;
Induction Chemotherapy;
Neck*;
Oncogenes;
Radiotherapy*;
Retrospective Studies
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1998;41(5):620-625
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Although several oncogenes have been implicated in cellular resistance to ionising radiation or anticancer drug, there is little known about clinical information relating oncogene expression with clinical response to chemoradiotherapy. Correlation between expression of cyclin D1 and Ki-67 and clinical response to chemotherapy and radiotherapy in advanced squamous cell carcinomas was investigated. DESIGN: Retrospective study. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tumor materials of 36 patients with advanced SCC of head and neck (clinical stage III, IV) were analyzed by immunohistochemical method with cyclin D1 and MIB-1 monoclonal antibodies. All patients were treated with induction chemotherapy and 22 patients were followed by radiotherapy. RESULTS: Overexpression of cyclin D1 protein was found in 33% (12/36). The expressed range of Ki-67 was from 0% to 80.1%. Expression of cyclin D1 protein was higher in the non-response group than in the response group to chemotherapy, but was not correlated with radiotherapy response. The Ki-67 index was not associated with tumor response to chemotherapy and radiotherapy. CONCLUSIONS: These data suggest that overexpression of cyclin D1 would be a marker for the chemotherapy response, although not for the radiotherapy response, whereas Ki-67 index may not be associated with tumor response to the chemotherapy and not to the radiotherapy in advanced squamous cell carcinomas of head and neck.
