A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL).
- Author:
Young Soo HEO
1
;
Hae Jun SONG
;
Chil Hwan OH
Author Information
1. Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. choh@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Fixed drug eruption;
Tegafur;
Tegasil
- MeSH:
Dihydrouracil Dehydrogenase (NADP);
Drug Eruptions;
Erythema;
Fluorouracil;
Hyperpigmentation;
Keratoderma, Palmoplantar;
Tegafur;
Uracil
- From:Korean Journal of Dermatology
2010;48(2):155-157
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase, which results in higher 5-FU concentrations in tumors. Mucocutaneous side effects induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, there have been no reports of fixed drug eruption associated with TEGASIL. We report here on a case of fixed drug eruption due to oral TEGASIL.
