Effects of Inonotus Obliqua Extract on Blood Glucose Levels in Genetically Diabetic Mice.
- Author:
Heeok HONG
1
Author Information
1. Department of Food Service Management and Nutrition, Sangmyung University, Seoul 110-743, Korea. hhong5802@hanmail.net
- Publication Type:Original Article
- Keywords:
C57BL/KsJ-m+/+Lepr(db);
Inonotus obliqua extract;
blood glucose level;
glucose-6-phosphatase;
hemoglobin A1c
- MeSH:
Animals;
Blood Glucose*;
Diabetes Mellitus, Type 2;
Fasting;
Glucose-6-Phosphatase;
Humans;
Hyperglycemia;
Insulin;
Liver;
Mice*;
Mice, Obese;
Weights and Measures
- From:The Korean Journal of Nutrition
2007;40(7):601-605
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study investigated the therapeutic effects of Inonotus obliqua extract on blood glucose, insulin, and other biochemical parameters in genetically diabetic mice (C57BL/KsJ-m+/+Lepr(db)). The mice were divided into four groups - control, Chaga 1 (dose of 0.09 mg/kg of body weight), Chaga 5 (5 times of Chaga 1), and Chaga 10 (10 times of Chaga 1)- according to supplemented dose. Inonotus obliqua extract was orally administered to the animals for 6 weeks. The body and organ (liver and kidney) weights were not different among groups. Fasting blood glucose level was significantly lower in the Chaga 5 group compared with the control (p < 0.05). Hemoglobin A1c content was significantly lower in the Chaga 5 group compared with either the control and Chaga 1 group (p < 0.05). There was no significant difference in serum insulin level among groups. The glucose-6-phosphatase activity in liver was significantly the lowest in Chaga 10 group and was significantly lower in Chaga 5 group as compared with those of control and Chaga 1 groups. Therefore, the results of this study demonstrate that Inonotus obliqua extract alleviates many of the symptoms of diabetes in genetically obese mice and may offer a possibility as a therapeutic supplement for the normalization of blood glucose levels in human with hyperglycemia and have beneficial effects in patients with noninsulin-dependent diabetes mellitus.
