Effects of Soy Protein and Isoflavones on Bone Mineral Density in Crowing Female Rats.
- Author:
Mi Ja CHOI
1
;
Hyun Ju CHO
Author Information
1. Department of Food and Nutrition, Keimyung University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
soy protein;
isoflavones;
bone mineral density;
growing female rat
- MeSH:
Animals;
Bone Density*;
Caseins;
Crows*;
Diet;
Eating;
Female*;
Femur;
Humans;
Isoflavones*;
Rats*;
Rats, Sprague-Dawley;
Soybean Proteins*;
Spine;
Water;
Weight Gain;
Wisconsin
- From:The Korean Journal of Nutrition
2003;36(4):359-367
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to examine the impact of soy protein and soy isoflavones on bone and mineral density in young female Sprague-Dawley rats. Fifty eight rats (body Weight 75+/-5 g) were randomly assigned to one of four groups, consuming casein, soy protein concentrate, soy protein isolate (57 mg isoflavones/100 g diet) or casein added isoflavones (57 mg isoflavones /100 g diet). All rats were fed on experimental diet and deionized water ad libitum for 9 weeks. Bone mineral density (BMD) and bone mineral content (BMC) were measured using PIXImus (GE Lunar Co, Wisconsin, USA) in spine and femur on 3, 6, 9 weeks after feeding. The serum and urine concentrations of Ca and P were determined. Diet did not affect weight gain and mean food intake. Food efficiency ratio was lower In soy protein groups. The serum concentration of Ca and P were not changed by soy protein and isoflavones. Urinary Ca and P excretion were not significantly different. Spine BMD was significantly increased by soy protein isolate on 3 and 6 weeks after feeding. Femur BMD was significantly increased in the groups of soy protein isolate and isoflavones adding on after 9 weeks. Therefore, soy protein with rich isoflavones may be beneficial on spine and femur BMD increasement in growing female rats.
