Expression of M llerian Inhibiting Substance in Cryptorchidism at the Descending Level of Testis.
- Author:
Choong Bum LEE
1
;
Kyoung Joon LEE
;
Yong Hyung CHO
;
Dae Haeng CHO
;
Moon Soo YOON
Author Information
1. Departmnet of Urology, Catholic University of Korea, School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cryptorchidism;
M llerian inhibiting substance
- MeSH:
Cryptorchidism*;
Humans;
Male;
Orchiectomy;
Scrotum;
Testis*
- From:Korean Journal of Urology
1998;39(2):167-172
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the relationship of MIS and cryptorchidism according to the descending level of testis into scrotum, we studied expression degree of MIS by immunohistochemical analysis using anti-human MIS polyclonal antibody in testicular specimen. MATERIALS AND METHODS: MIS were stained in excised testis by trauma on each 8 patients as control group and age-matched abdominal, inguinal and prepubic cryptorchidism. The expression were classified as score 1, 2, 3 and 4 according to stained degree of percentage in randomized 16 fields(x400) under the light microscope. RESULTS: Of the degree of MIS expression in control group, 87.5% were category 3 or more. The mean score was 3.13+/-0.62. 2. Of the degree of MIS expression in abdominal type cryptorchid testis group that underwent orchiectomies, 68.7% were category 1. The mean score, 1.31 +/- 0.48, showed significant difference compared to control group(p<0.05). 3. Of the degree of MIS expression in inguinal type,56.2% were category 3 or more. The mean score, 2.63+/- 0.81, showed no significant difference compared to control group(p>0.05). 4. Of the degree of MIS expression in prepubic type, 75.0% were category 3 or more. And the mean score, 2.88+/-0.62, showed no significant difference compared to control group(p>0.05). CONCLUSIONS: Expression of MIS is different according to descending level of testis and may play a role in physiologic changes of testicular descent.
