Streptozotocin-induced Diabetes Increases the Adiponectin-mediated AMP-activated Protein Kinase Cascade in the Hippocampus of Mice.
- Author:
Chin Ok YI
1
;
Byeong Tak JEON
;
Young Hee KIM
;
Tae Sik JUNG
;
Dong Hoon LEE
;
Hyun Joon KIM
;
Sang Soo KANG
;
Gyeong Jae CHO
;
Wan Sung CHOI
;
Gu Seob ROH
Author Information
1. Department of Anatomy and Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, Gyeongsang National University School of Medicine, Jinju, Gyeongnam 660-751, Korea. anaroh@gnu.ac.kr
- Publication Type:Original Article
- Keywords:
Streptozotocin;
Adiponectin;
AMPK;
Diabetes;
Hippocampus;
Mouse
- MeSH:
Acetyl-CoA Carboxylase;
Adenosine;
Adiponectin;
AMP-Activated Protein Kinases;
Animals;
Blood Vessels;
Endothelium;
Energy Metabolism;
Glucose;
Glucose Transport Proteins, Facilitative;
Hippocampus;
Insulin Resistance;
Mice;
Protein Kinases;
Proteins;
Receptors, Adiponectin;
Streptozocin
- From:Korean Journal of Anatomy
2009;42(3):141-147
- CountryRepublic of Korea
- Language:English
-
Abstract:
Adiponectin is an adipocyte-derived protein with anti-diabetic and anti-angiogenesis properties that improves both glucose metabolism and insulin resistance via the adenosine monophosphate-activated protein kinase (AMPK) cascade. Diabetic cognitive deficits are correlated with dysregulation of energy metabolism in the hippocampus. In the present study, we investigated the expression of adiponectin-mediated AMPK cascade proteins in the hippocampus of streptozotocin (STZ)-induced diabetic mice. Diabetes was induced by STZ (55 mg/kg) injection intraperitoneally. Twenty-four weeks after induction of diabetes, mice were sacrificed. Results showed that decreased serum adiponectin levels and increased expression of hippocampal adiponectin receptor 1 (AdipoR1) was expressed in diabetic mice. Phosphorylated AMPK, acetyl CoA carboxylase (ACC), and eNOS expression levels were increased in the hippocampus of diabetic mice. The immunoreactivity of glucose transporter 1 in the endothelium of hippocampal blood vessels was also increased. These results indicate that adiponectin-mediated AMPK cascade activation may play a role in catabolic process that is involved in diabetic neurodegeneration.
