Expression and Role of Adhesion Molecules in the Nasal Mucosa of the Rat with Experimentally Induced Allergic Rhinitis.
- Author:
Yang Gi MIN
1
;
Chul Hee LEE
;
Chae Seo RHEE
;
Ja Bock YUN
;
Ik Tae KIM
;
Tae Young KWON
;
Seok Won PARK
;
Sang Jun JEON
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine, Seoul, Korea. ygmin@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Nasal mucosa;
Adhesion molecule;
Allergy animal model;
Inhibition
- MeSH:
Animals;
Antibodies;
Antibodies, Monoclonal;
Endothelial Cells;
Eosinophils;
Humans;
Hypersensitivity;
Injections, Intraperitoneal;
Intercellular Adhesion Molecule-1;
Leukocytes;
Lymphocyte Function-Associated Antigen-1;
Nasal Mucosa*;
Ovalbumin;
Rats*;
Rhinitis*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1999;42(12):1514-1519
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Airway allergic reactions are induced by infiltrating inflammatory cells into the human airway tissues through interactions between vascular endothelial cells, inflammatory mediators and adhesion molecules. Accordingly, it is important to study the role of adhesion molecules for the evaluation of pathophysiology of allergy. The aim of this study is to investigate the effect of monoclonal antibodies against intercellular adhesion molecule-1 (ICAM-1) and leukocyte function associated molecule-1 (LFA-1) on the pathophysiology of allergy in ovalbumin-sensitized rats. MATERIALS AND METHODS: We developed an allergy model in rat using the intraperitoneal injection and intranasal nebulization of ovalbumine solution. We evaluated in vivo effects of ICAM-1 and LFA-1 monoclonal antibodies on the expression of ICAM-1 and LFA-1 in ovalbumin sensitized rats. RESULTS: Nasal symptoms after allergen challenge were significantly suppressed and the number of eosinophil in nasal mucosa were significantly inhibited by the treatment of adhesion molecule antibodies. Anti-ICAM-1 and anti-LFA-1 monoclonal antibodies suppressed the expression of ICAM-1 and LFA-1 in nasal mucosa of ovalbumin-sensitized rats. CONCLUSION: It is suggested that allergy can be managed by a useful treatment method using adhesion molecule antibody.
