Differential Effects of Antipsychotic Drugs on Dopamine D1 and D2 Receptor mRNAs in the Rat Brain.
- Author:
Myeong Ok KIM
1
;
Yoon Sook KIM
;
Chang Hwan PARK
;
Young Ae YANG
;
Sang Soo KANG
;
Gyeong Jae CHO
;
Gu Seob ROH
;
Wan Sung CHOI
Author Information
1. Department of Biology, College of Natural Sciences, Gyeongsang National University, Chinju 660-751, Korea.
- Publication Type:Original Article
- Keywords:
Antipsychotic drugs;
Dopamine receptor;
in situ Hybridization;
Rat;
Brain
- MeSH:
Animals;
Antipsychotic Agents*;
Brain*;
Clozapine;
Dopamine*;
Gene Expression;
Haloperidol;
Humans;
In Situ Hybridization;
Male;
Nucleus Accumbens;
Olfactory Pathways;
Putamen;
Rats*;
Rats, Sprague-Dawley;
Receptors, Dopamine;
RNA, Messenger*;
Sulpiride;
Water
- From:Korean Journal of Anatomy
2005;38(4):363-370
- CountryRepublic of Korea
- Language:English
-
Abstract:
The principal aim of this study was to determine the effects of antipsychotics (haloperidol, sulpiride, and clozapine) on regulating dopamine (DA) D1 and D2 receptor mRNA levels in the rat caudate putamen (CPu), nucleus accumbens (NAc), and olfactory tubercle (OTu). Twenty male Sprague-Dawley rats (250 g) were treated with haloperidol (1mg/mL), sulpiride (40 mg/mL), clozapine (20 mg/mL), and the control group received only water. Drugs were administered orally for 4 weeks. Antipsychotic drugs had differential effects on DA D1 and D2 receptor gene expression. Haloperidol and sulpiride induced an increase of DA D1 and D2 receptor mRNA levels in the rat CPu, OTu, and NAc; haloperidol caused a greater increase than sulpiride. However, clozapine treatment had less effect on DA receptor mRNAs levels in the same area. Antipsychotic drugs differentially upregulated the expression of DA D1 and D2 receptor mRNAs in the rat brain. These changes may be related, at least in part, to changes of DA concentration following antipsychotics treatment.
