Gene Therapy for Bone Tissue Engineering.
10.1007/s13770-016-9063-8
- Author:
Young Dong KIM
1
;
Prasad POFALI
;
Tae Eun PARK
;
Bijay SINGH
;
Kihyun CHO
;
Sushila MAHARJAN
;
Prajakta DANDEKAR
;
Ratnesh JAIN
;
Yun Jaie CHOI
;
Rohidas AROTE
;
Chong Su CHO
Author Information
1. Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Korea.
- Publication Type:Brief Communication
- Keywords:
Gene therapy;
Viral vector;
Non-viral vector;
Bone tissue engineering;
Bone morphogenetic protein
- MeSH:
Bone and Bones*;
Bone Morphogenetic Proteins;
Genetic Therapy*;
Osteogenesis;
Regeneration;
Tissue Engineering
- From:
Tissue Engineering and Regenerative Medicine
2016;13(2):111-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered by combining different vectors (viral or non-viral), scaffolds and delivery methodologies. Ex vivo & in vivo gene enhanced tissue engineering approaches have led to successful osteogenic differentiation and bone formation. In this article, we review recent advances of gene therapy-based bone tissue engineering discussing strengths and weaknesses of various strategies as well as general overview of gene therapy.
