Substance P and Thiorphan Synergically Enhance Angiogenesis in Wound Healing.
10.1007/s13770-016-9089-y
- Author:
Jihyun UM
1
;
Jinyeong YU
;
Maria Jose DUBON
;
Ki Sook PARK
Author Information
1. Graduate School of Biotechnology & Department of Genetic Engineering, Kyung Hee University, Yongin, Korea.
- Publication Type:Original Article
- Keywords:
Substance P;
Thiorphan;
Neutral endopeptidase;
Angiogenesis;
Wound
- MeSH:
Actins;
Extracellular Matrix;
Neprilysin;
Skin;
Substance P*;
Thiorphan*;
Wound Healing*;
Wounds and Injuries*
- From:
Tissue Engineering and Regenerative Medicine
2016;13(2):149-154
- CountryRepublic of Korea
- Language:English
-
Abstract:
Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound healing in a skin injury model. SP is degraded by neutral endopeptidase (NEP). Our study shows that systemic co-treatment of SP and thiorphan, an inhibitor of NEP synergically increased the number of α-smooth muscle actin positive-blood vessels in skin wounds. However, there was no synergic improvement in wound contraction and extracellular matrix deposition. Therefore, inhibition of endogenous NEP activity by thiorphan treatment might modulate the effects of SP treatment specifically on accelerating angiogenesis during wound healing. However, the molecular mechanism(s) of the synergic increase in angiogenesis by SP and thiorphan treatment is still unknown.
