Clinical significance of tests in diagnosis of HCV
- Author:
Ho Tan Dat
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus
- MeSH:
Hepacivirus;
Diagnosis
- From:Journal Ho Chi Minh Medical
2005;9(1):30-34
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Study on 169 patients (87males, 82 females) aged from 21 to 71 years old in order to determine, quantify as well as type hepatitis C virus. Immunoassay was used to detect anti HCV and serotype of HCV from patients’ sera; molecular biology assay was used to detect HCV-RNA (using RT-PCR target the 5’UT region of viral genome), and to quantify the HCV in the patients’ blood (using bDNA). Results: the rate positive HCV-RNA were 70% among 319 cases with anti HCV (+). In 169 cases that have been done serotype tests, the most common serotypes were type 6 (44.38%), followed by type 1 (37.28%). Type 1 is referred as the most difficult to response to the specific treatment. The results of quantitative assay showed that type 1 and type 6 infected patients had high quantity of viremia. From this study, the roles of the molecular biology assays were defined as the very necessary in diagnosis as well as treatment of patients with HCV infection
