The Role of BF-7 on Enhancement of Memory and Cognitive Funtion.
- Author:
Dea Kyung KIM
1
;
Jun Young LEE
;
Jung Jun SUNG
;
Eui Tae KIM
;
Yong Sik KIM
;
Oh Sang KWON
;
Young Chul YUN
;
Tae Jin LEE
;
Yong Koo KANG
;
Yoon Hee CHUNG
;
Sung Su KIM
;
Kyung Yong KIM
;
Won Bok LEE
Author Information
1. Department of Psychiatry, College of Medicine, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Memory;
Cognitive function;
BF-7;
Scopolamine;
Water maze;
MMSE-K
- MeSH:
Aging;
Alzheimer Disease;
Bombyx;
Brain;
Cognition;
Humans;
Learning;
Memory*;
Models, Animal;
Nervous System;
Neurodegenerative Diseases;
Scopolamine Hydrobromide
- From:Korean Journal of Anatomy
2004;37(6):519-527
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Various factors such as senescence, stress, neurodegenerative diseases including Alzheimer's disease (AD) contribute to the impairments of organs, especially brain. Also, they should be negative factors on normal brain function, like as memory and cognition. In this study, the neuroprotective role of BF-7, extracted from Bombyx mori, was examined agaist scopolamine-induced neurotoxicity in SK-N-SH cells. In order to know if the BF-7 has positive role on the cognition and memory, we examined using SD rat model and human. Scopolamine-induced memory impairments were observed, as measured by the passive avoidance and water maze tests, but treatment with BF-7 significantly improved memory and cognitive function. Moreover, the memory index and memory preservation of clinical experiments using MMSE-K tests were significantly improved memory and cognitive function. This results strongly represent that the BF-7 play effectively positive role in the improvement of brain function including learning and memory. Taken together, our results suggested that the BF-7 should be useful for developing strategies protecting nervous system and improving brain function.
