Analysis of Relationship between Burning Mouth Syndrome and Abnormality of Serum Examination.
10.3342/kjorl-hns.2013.56.1.23
- Author:
Hanaro PARK
1
;
Yewon KIM
;
Woo Jin JEONG
;
Soon Hyun AHN
Author Information
1. Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. ahnsh30@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Burning mouth syndrome;
Fungus;
Serum concentration
- MeSH:
Burning Mouth Syndrome;
Burns;
Folic Acid;
Fungi;
Humans;
Iron;
Physical Examination;
Reference Values;
Sensation;
Vitamin B 12;
Vitamin B 12 Deficiency;
Voice;
Zinc
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2013;56(1):23-27
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The objective of this study was to determine whether the serum levels of zinc, vitamin B12, folic acid, iron, and fungus were correlated with symptoms of burning mouth syndrome (BMS) and to analyze the relationship between treatment responses and the results from serum examination. SUBJECTS AND METHOD: We analyzed data from 284 patients whose serum examination results recorded responses to treatment were available from June 2004 to November 2011. A total of 219 patients experienced burning sensation, while 65 patients experienced only globus symptoms or voice changes. RESULTS: Of the patients who experienced burning sensations, 5 (2.3%) had vitamin B12 deficiency, 23 (10.5%) had iron deficiency, 40 (24%) had zinc deficiency, but no patients had folic acid concentrations below the reference range. A total of 44 patients (25%) were fungus-positive. The comparison of the experimental and control treatment groups revealed that iron-deficient patients and fungal-positive patients were more frequently found in the experimental group (p=0.023 and p=0.010, respectively). Abnormalities in the serum or physical examinations were observed in 126 patients (57.5%). Symptomatic treatments were performed for both groups, which corrected abnormalities in serum examinations. CONCLUSION: The rates of fungus positivity and iron deficiency were higher in the BMS group. However, we did not identify a correlation between the response to treatment and serum examination of the analyzed elements or fungus examination. The total secondary oral burning rate was found to affect treatment modality.
