The Protective Role of Estrogen by Down -regulation of Bax in Ceramide Induced Neuronal Cell Death.
- Author:
Hee Sun CHAE
1
;
Sung Su KIM
;
Kyung Yong KIM
;
Won Bok LEE
Author Information
1. Department of Anatomy, College of Medicine, Chung-Ang University, Heuk Suk Dong, Dong Jak Ku, Seoul, Korea. whitefox@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Estrogen;
Ceramide;
Neuronal cell death;
Bax;
Caspase
- MeSH:
Cell Death*;
Down-Regulation;
Estrogens*;
Humans;
Neuroblastoma;
Neurons*
- From:Korean Journal of Anatomy
2002;35(6):509-516
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In the present study, we investigated effects of estrogen on cell death induced by ceramide in human neuroblastoma SK -N -SH. Estrogen, attenuated ceramide -induced cell death. To determine the molecular mechanism of protective effect of estrogen, we investigated the effect of estrogen on the increase of Bax by ceramide. Estrogen decreased Bax expression. Moreover, estrogen showed the inhibitory effect on the caspase activation by ceramide. These results suggest that estrogen attenuate ceramide -induced neuronal cell death by downregulation of Bax and subsequent inhibition of caspase activation.
