Carbonic anhydrase II immunostaining in the cerebellum of postnatal mice.
- Author:
Chang Ho YOON
1
;
Gye Sun JEON
;
Cheol LEE
;
Je Hoon SEO
;
Tae Cheon KANG
;
Kyeong Han PARK
;
Choong Ik CHA
;
Sang Ho BAIK
;
Sa Sun CHO
Author Information
1. Department of Anatomy, Seoul National University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
mouse;
cerebellum;
carbonic anhydrase II;
myelin;
oligodendrocyte
- MeSH:
Animals;
Carbon*;
Carbonic Anhydrase II*;
Carbonic Anhydrases*;
Central Nervous System;
Cerebellum*;
Mice*;
Myelin Sheath;
Oligodendroglia
- From:Korean Journal of Anatomy
1999;32(4):535-541
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The carbonic anhydrase II (CA-II) is specifically expressed in oligodendrocytes, the cells responsible for myelination in the central nervous system. However no direct evidence on relationship between myelin formation and CA-II immunoreactivity has been described. The aims of these studies are to investigate the relationship between CA-II and myelination during cerebellar development of mouse. Myelin staining was found on postnatal (P) 14, and its intensity increased in proportion to developmental age. CA-II positive oligodendrocytes were observed in the white matter of cerebellum on P 14 day. CA-II positive oligoden-drocytes also occured in the granular layer and Purkinje cell layers in the later stage of dvelopment. The parallel development in the CA-II expression and myelination during development suggests that CA-II in oligoendrocyte play a role to myelination.
