Apoptotic Cells and the Histopathologic Findings in Rotator Cuff Tears.
10.4055/jkoa.2009.44.4.401
- Author:
Ji Hoon SUH
1
;
Soo Heon HONG
;
Jae Bum PARK
;
Jong Min KIM
;
Jae Myeung CHUN
Author Information
1. Development and Differentiation Laboratory, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Rotator cuff;
Rotator cuff tear;
Rotator cuff repair;
Apoptosis
- MeSH:
Apoptosis;
Blood Vessels;
Fibroblasts;
Humans;
In Situ Nick-End Labeling;
Rotator Cuff;
Tendons
- From:The Journal of the Korean Orthopaedic Association
2009;44(4):401-407
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We analyzed the relationship between the size of the torn rotator cuff and the frequency of finding apoptotic cells (apoptotic index) or pathological degeneration in the rotator cuff. MATERIALS AND METHODS: The edges of torn supraspinatus tendons were obtained from patients with rotator cuff tear (n=63). The study group consisted of 2 small, 22 medium, 22 large and 17 massive tears. For the histopathologic evaluation, the H&E stained sections of the torn supraspinatus tendons were examined. Apoptosis was detected with TUNEL assay. We analyzed the relationships between the tear size and the pathologic findings or the apoptotic index. RESULTS: Significant differences could not be found for the fibroblast cellularity, thickening of the synovial lining and proliferation of blood vessels according to the size of the rotator cuff tear. All the specimens had apoptotic cells that were concentrated around the margin of the tear site. The apoptotic indexes according to the tear size were 58.50 for the small tears, 27.25 for the medium tears, 33.29 for the large tears and 31.96 for the massive tears. No significant correlation was found between the tear size and the apoptotic index. CONCLUSION: There were no significant differences in the apoptotic indices, the fibroblast cellularity, the thickening of the synovial lining and the proliferation of blood vessels according to the size of the rotator cuff tear, and there were no correlations between the apoptotic index and the histopathologic findings.
