Experimental Studies on the Factors Related to Hair Loss in Spontaneous Hair Loss C57BL/6N Mice Models.
- Author:
Yong Ick KIM
1
;
Moon Won LEE
;
Jin KWON
;
Chang Ho SONG
;
Chang Hyun LEE
Author Information
1. Department of Anatomy, College of Oriental Medicine, Woosuk University, Korea. chlee@woosuk.ac.kr
- Publication Type:Original Article
- Keywords:
Spontaneous hair loss;
Mast cells;
Substance P;
CRF;
CRF-R;
CRF-BP;
CD4;
CD8
- MeSH:
Animals;
Hair*;
Lymphocytes;
Mast Cells;
Mice*;
Neuropeptides;
Sebaceous Glands;
Stem Cell Factor;
Stem Cells;
Substance P
- From:Korean Journal of Anatomy
2005;38(2):133-143
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In spontaneous hair loss of C57BL/6N mice model, we investiged the factors related to hair loss by microscopic and immunocytochemical methods. The results were as follows; Microsopic observation of sebaceous gland was developed, and subcutaneous layer was thin in SA and AU group. Number of mast cells in SA and AU group was more increased than that of other groups. Number and immunoreactive density of CD4/CD8 lymphocytes was more increased than that of other groups. Immunoreactivity of substance P and CRF was weakly stained in stem cell region of SA and AU group. Immunoreactivity of CRF-R and CRF-BP was weakly stained in stem cell and bulge regions of SA and AU group. Immunoreactivity of stem cell factor was weakly stained in stem cell, bulge region and dermal papilla of SA and AU group. These experiment suggest that factors related to hair loss in spontaneous hair loss C57BL/6N mice models are increased of mast cell, CD4 and CD8 lymphocytes, and decreased of cytokine and neuropeptide in stem cell, bulge region and dermal papilla.
