Life-Threatening Acute Hyponatremia with Generalized Seizure Induced by Low-Dose Cyclophosphamide in a Patient with Breast Cancer.
10.4048/jbc.2011.14.4.345
- Author:
Seong Bae HWANG
1
;
Hye Yoon LEE
;
Hoon Yub KIM
;
Eun Sook LEE
;
Jeoung Won BAE
Author Information
1. Division of Breast-Endocrine Surgery, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. kujwbae@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Breast neoplasms;
Cyclophosphamide;
Hyponatremia;
Seizures
- MeSH:
Breast;
Breast Neoplasms;
Chemotherapy, Adjuvant;
Cyclophosphamide;
Doxorubicin;
Female;
Furosemide;
Humans;
Hyponatremia;
Middle Aged;
Saline Solution, Hypertonic;
Seizures;
Sodium
- From:Journal of Breast Cancer
2011;14(4):345-348
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cyclophosphamide is commonly used in the treatment of malignant diseases. Symptomatic severe hyponatremia induced by low-dose cyclophosphamide is very uncommon worldwide. Recently we experienced a case of a 56-year-old woman with breast cancer who developed severe hyponatremia with generalized seizure after the first cycle of adjuvant chemotherapy with doxorubicin and cyclophosphamide. Her laboratory test showed a serum sodium of 116 mmol/L. Her hyponatremia was initially treated with hypertonic saline solution and furosemide. She completely recovered without neurological deficits after slow correction of the serum sodium concentration over two days. Clinicians must always keep in mind that life-threatening acute hyponatremia can be induced by intravenous cyclophosphamide during chemotherapy, even if the dosage is low.
