Herpesviral Interaction with Autophagy.
10.4167/jbv.2011.41.4.213
- Author:
Chengyu LIANG
1
Author Information
1. Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA. chengyu.liang@usc.edu
- Publication Type:Review
- Keywords:
Autophagy;
Virus;
Innate immunity;
Infection
- MeSH:
Autophagy;
Eukaryotic Cells;
Herpesviridae Infections;
Humans;
Immunity, Innate;
Quality Control;
Viruses
- From:Journal of Bacteriology and Virology
2011;41(4):213-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
Autophagy constitutes a major catabolic hub for the quality control of intracellular entities of eukaryotic cells, and is emerging as an essential part of the host antiviral defense mechanism. However, in turn, viruses have evolved elegant strategies to co-opt various stages of the cellular autophagy pathway to establish virulence in vivo. This is particularly the case in the ubiquitous and persistent herpesvirus infection. In this review, I will focus on recent findings regarding the crosstalk between the herpes virus family and the autophagy pathway, with a look at the molecular mechanisms they use to disturb cells' autophagy regulation and eventually result in persistence and pathogenesis.
