The Effects on Antimicrobial and Cytotoxicity of Hijikia Fusiformis Fraction.
- Author:
Jae Hak SHON
1
;
Dae Yeon KANG
;
Hyun Cheol OH
;
Bok Mi JUNG
;
Mi Hyang KIM
;
Mi Ok SHIN
;
Song Ja BAE
Author Information
1. Department of Food and Nutrition, Silla University, Busan 617-736, Korea. sjbae@silla.ac.kr
- Publication Type:Original Article
- Keywords:
cytotoxicity;
quinone reductase;
Hizikia fusiformis (HF),cancer cell lines
- MeSH:
Cell Line;
Hep G2 Cells;
Humans;
Methanol;
NAD(P)H Dehydrogenase (Quinone)
- From:The Korean Journal of Nutrition
2006;39(5):444-450
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In this study, we investigated antimicrobial and cytotoxicity effects to each fraction extracted from Hizikia fusiformis (HF), which were extracted methanol (HFM)and then the extract was fractionated into four different types: hexane (HFMH), methanol (HFMM), butanol (HFMB) and aquous (HFMA) partition layers. We determined the cytotoxic effect of these layers on human cancer cells by MTT assay. Among various partition layers of HF, the HFMB and HFMM were showed the strong cytotoxic effects on cancer cell lines we used. The quinone reductase (QR) induced activity of the HFMB on HepG2 cells at 150 microgram/mL concentration was 2.63 times more effective compared to the control value of 1.0. Although further studies are needed, the present work suggests that HF maybe a chemopreventive agent for the treatment of human cancer cells.
