Comparison of Pharmacological Treatments for Burning Mouth Syndrome.
10.3342/kjorl-hns.2012.55.11.707
- Author:
Hyo Geun CHOI
1
;
Eun Jung JUNG
;
Won Yong LEE
;
Heejin KIM
;
Wonjae CHA
;
J Hun HAH
Author Information
1. Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea. jhunhah@snu.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Burning mouth syndrome;
Clonazepam;
Gabapentin;
Paroxetine;
Trazodone
- MeSH:
Amines;
Burning Mouth Syndrome;
Burns;
Clonazepam;
Cyclohexanecarboxylic Acids;
gamma-Aminobutyric Acid;
Humans;
Mouth;
Paroxetine;
Rare Diseases;
Sensation;
Trazodone
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2012;55(11):707-711
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Burning mouth syndrome (BMS) refers to a collection of symptoms of patients who complain about burning sensation of their mouths without any specific causes. Although this is not a rare disease, the etiology and effective treatment are not well established. We tried to compare the efficacy and side effects of the agents that are reported to be relatively effective to BMS. SUBJECTS AND METHOD: Fifty-one patients who were diagnosed as BMS were chosen as candidates. Trazodone, Paroxetine, Clonazepam, and Gabapentin, which were known to be effective medicines for BMS in previous research were prescribed randomly. We prescribed medication for two weeks and evaluated patients for the effect and side effects at the end of the treatment. The medication was prescribed for 2 more weeks and the patients were evaluated again. RESULTS: Three of 11 (27.3%) patients were prescribed Trazodone, 8 of 12 (66.7%) Paroxetine, 8 of 14 (57.1%) Clonazepam and 12 of 14 (85.7%) Gabapentin. Q showed improvements after 4 weeks of medication. The differential effectiveness among the medications was not significant, except for the inferiority of Trazodone. Five of 11 (45.5%) patients who had been prescribed Trazodone, 2 of 12 (16.7%) who had been prescribed Paroxetine, 2 of 14 (14.3%) who had been prescribed Clonazepam, 2 of 14 (14.3%) who had been prescribed Gabapentin complained of side effects during 4 weeks of medication. CONCLUSION: We can expect high success rates of treatment for burning mouth syndrome with Paroxetine, Clonazepam and Gabapentin. A further study for long term outcomes and side effects in large groups is warranted.
