Sub-chronic toxicity of 16-piperazinoethanol-10 alpha-triluoromethyl anhydroihydroartemisinin (BB134) in experimental animal
- Author:
Truong Van Nhu
- Publication Type:Journal Article
- Keywords:
Piperazinoethanol;
Trifluoromethyl;
Anhydrodihydroartemisinin;
Experiments
- MeSH:
Malaria;
Animal Experimentation;
Artemisinins
- From:Journal of Malaria and parasite diseases Control
2003;0(6):15-22
- CountryViet Nam
- Language:Vietnamese
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Abstract:
The BB134's sub-chronic toxicity in rabbits was investigated at NIMPE's laboratory. BB134 was orally administered at the dose of 9mg/kg of body weight per day for 28 consecutive days. The influence of BB134 on rabbit's laboratory indices and cardiovascular system were observed during and after the BB134 administration. The BB134 had not change the normal indices of development as well as the biochemical and some hematological indices of the experimental rabbits. During the study time the rabbits acted and ate normally. The body weight was increased significantly. SGOT, SGPT, bilirubin and creatinine as well as leukocytes, leukocyte formula and hemoglobin had no change. However erythrocytes decreased significantly by day 14. BB134 was also found not to affect significantly on rabbits' cardiovascular system (rabbits' heart rhythms and cardiovascular waves such as P, QP, QRS, T and QT of the control and treated groups were not changed significantly
