Multiple Primary Malignancies in the Head and Neck: A Clinical Review of 70 Patients.
- Author:
Chang Hoon BAI
1
;
Seung Min CHEN
;
Seok Choon LEE
;
Eun Chae JUNG
;
Eun Hoi BAEK
;
Sung Won CHOI
;
Yun Seok CHOI
;
Yong Dae KIM
;
Si Youn SONG
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu, Korea. ssykhs@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Multiple primary neoplasms;
Head and neck neoplasms
- MeSH:
Alcohol Drinking;
Carcinoma, Squamous Cell;
Esophagus;
Female;
Head and Neck Neoplasms;
Head*;
Humans;
Hypopharynx;
Incidence;
Lung;
Male;
Medical Records;
Neck*;
Neoplasms, Multiple Primary;
Prognosis;
Retrospective Studies;
Smoke;
Smoking;
Stomach;
Tobacco Products
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2007;50(8):694-698
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Recent advances in medical management, along with increased life span, have contributed to the increased opportunity for detecting multiple primary malignancy (MPM). The purpose of this study was to evaluate the incidence and clinical characteristics of MPM in the head and neck region. SUBJECTS AND METHOD: We reviewed retrospectively the medical records of 984 patients with malignant tumors of head and neck who had been diagnosed histopathologically and treated between August 1985 to July 2005. RESULTS: Seventy patients (7.11%) were diagnosed as having MPM (double, n=66 ; triple, n=4). This group consisted of 67 men and 3 women (p<0.01). Twenty-five patients (36%) had synchronous double primary malignancy (SDPM) and 45 patients (64%) had metachronous double primary malignancy (MDPM). The hypopharynx was the most frequently involved site of the index tumor. The most common index tumors were squamous cell carcinoma histopathologically. Second primary malignancies were found in esophagus, stomach and lung. Fifty-five patients were found with first primary malignancy in head and neck, and 25 were with second primary malignancy. The patients with first and second primary malignancy in head and neck were 10 cases. The prognosis of SDPM (average of survival 11.1 months) was very poor. Patients with MPM have high cigarettes smoking and alcohol drinking habit. CONCLUSION: Patients with head and neck malignancies will require careful follow up for prevention, early detection, and the treatment of second primary malignancy.
