The Expression of p53 and PCNA in Patients with Locally Recurrent Laryngeal Cancer after Radiotherapy.
- Author:
Byung Joo LEE
1
;
Soo Geun WANG
;
Jin Choon LEE
;
Bit Na YOON
;
Eui Kyung GOH
;
Do Youn PARK
;
Hae Jin JEONG
Author Information
1. Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea. wangsg@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Laryngeal neoplasms;
Genes, p53;
Proliferating cell nuclear antigen;
Radiotherapy
- MeSH:
Genes, p53;
Humans;
Laryngeal Neoplasms*;
Proliferating Cell Nuclear Antigen*;
Radiotherapy*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2004;47(1):52-55
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The biologic changes in recurrent laryngeal cancer following radiotherapy are not fully understood. The authors investigated the expression of p53 and proliferating cell nuclear antigen (PCNA) in patients with locally recurrent laryngeal cancer after radiotherapy. MATERIALS AND METHODS: The authors investigated the expression of p53 and PCNA by immunohistochemical stain in 15 patients with recurrent laryngeal cancer after radiotherapy. RESULTS: The expression of p53 protein was significantly different between laryngeal cancer before radiotherapy (4/15, 26.7%) and recurrent laryngeal cancer after radiotherapy (8/15, 53.3%) (p<0.05). Also, PCNA index was significantly different between laryngeal cancer before radiotherapy (mean, 11.9%) and recurrent laryngeal cancer after radiotherapy (mean, 18.0%) (p<0.05). CONCLUSION: The expressions of p53 protein and PCNA were increased more in the recurrent laryngeal cancer after radiotherapy than in the laryngeal cancer before radiotherapy. Recurrent laryngeal cancers changed to biologically aggressive cancer after following radiation therapy.
