Effect of Dietary Caseinphosphopeptide Levels on Bone Metabolism in Ovariectomized Rats.
- Author:
Daum YANG
1
;
Jin Woo LEE
;
Hong Joo PARK
;
Sun Hee KIM
;
Moon Jeong CHANG
Author Information
1. Department of Food and Nutrition, Kookmin University, Seoul 136-702, Korea. cmoon@koomin.ac.kr
- Publication Type:Original Article
- Keywords:
casein phophopeptides;
calcium;
phosphorus;
bone biomarkers;
ovariectomized rats
- MeSH:
Absorption;
Alkaline Phosphatase;
Animals;
Body Weight;
Bone Resorption;
Calcium;
Caseins;
Diet;
Female;
Femur;
Humans;
Metabolism*;
Osteoporosis, Postmenopausal;
Ovariectomy;
Phosphorus;
Rats*;
Rats, Sprague-Dawley
- From:The Korean Journal of Nutrition
2006;39(1):11-17
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of the level of casein phosphopeptide (CPP) on mineral (Ca and P) bioavailabilties and bone biomarker of aged ovariectomized (OVX) Sprague-Dawley rats were studied as a model for postmenopausal bone loss. Forty five Spargue dawley rats, 220-230g of body weight were fed a control diet (AIN 93M) or containing different level of CPP diet for 7 weeks: 0% (sham control; SC, OVX control; OC), 1% (OVX low CPP diet; OL), 2% (OVX medium CPP diet; OM), 3% (OVX high CPP diet; OH) Ca absorption was unaffected by increasing CPP content from 0 to 3%. Urinary Ca excretion was increased by OVX, and decreased by CPP significantly (p<0.05) with no evident dose-relationship. The urinary P excretion was increased by CPP intake in OVX rats. The fecal excretion of P given CPP decreased in OVX with dose dependent manner. Ca and P contents of femur significantly increased by adding 2 or 3% of CPP when compared with OC group and OL group (p<0.05). There were no significant differences in serum alkaline phosphatase activity and c-terminal telopeptide excretion in experimental groups. Although ovariectomy induced the increase in urinary c-terminal telopeptide excretion, 2 or 3% of CPP in the diet decreased urinary c-terminal telopetide excretion significantly. These finding suggest the usefulness of CPP in the prevention of postmenopausal bone loss by decreasing urinary Ca excretion and bone resorption. Over 2 percent of CPP in the diet was effective to prevent postmenopausal bone loss.
